Medical Subject Headings
Fragile X Tremor Ataxia Syndrome, Fragile X Syndrome. Primary Ovarian Insufficiency, Intellectual Disability, Muscle Tonus
Fragile X syndrome (FXS) is one of three syndromes identified as a health condition related to fragile X mental retardation (FMR1) gene dysfunction. The other two conditions are Fragile X-associated primary ovarian insufficiency syndrome (FXPOI) and Fragile X-associated tremor/ataxia syndrome (FXTAS) which together are referred to as Fragile X-associated disorders (FXD). Even though the three conditions share a common genetic defect each one is a separate health condition that results in a variety of body function impairments such as motor delay, musculoskeletal issues related to low muscle tone, coordination limitations, ataxia, tremor, undefined muscle aches and pains; and, for FXTAS, a late onset neurodegeneration.
Definition of the aging progression for FMR1 gene
Lieb-Lundell, Cornelia, "Aging with the FMR1 Gene: A Life Course Perspective" (2017). Physical Therapy Collection. 62.